{"id":2483,"date":"2015-01-13T14:24:53","date_gmt":"2015-01-13T19:24:53","guid":{"rendered":"http:\/\/blogviejo.sld.cu\/inorbib\/?p=2483"},"modified":"2015-01-13T14:24:53","modified_gmt":"2015-01-13T19:24:53","slug":"supresiones-constitucionales-y-somaticas-del-sindrome-de-la-region-critica-de-williams-beuren-en-el-linfoma-no-hodgkin","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/inorbib\/2015\/01\/13\/supresiones-constitucionales-y-somaticas-del-sindrome-de-la-region-critica-de-williams-beuren-en-el-linfoma-no-hodgkin\/","title":{"rendered":"Supresiones Constitucionales y som\u00e1ticas del s\u00edndrome de la regi\u00f3n cr\u00edtica de Williams-Beuren en el linfoma no Hodgkin."},"content":{"rendered":"

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JOURNAL HEMATOLOY AND ONCOLOGY <\/span><\/span><\/strong><\/span>2014, 7<\/span><\/strong>:82\u00a0(NOVIEMBRE) <\/span><\/strong><\/span><\/p>\n

Carta al Editor<\/span><\/strong>
\n<\/span>Supresiones<\/span><\/span> Constitucionales y<\/span> som\u00e1ticas<\/span> del s\u00edndrome de<\/span> la regi\u00f3n cr\u00edtica<\/span> de Williams-<\/span>Beuren en<\/span> el linfoma no Hodgkin<\/span>.<\/span><\/p>\n

Resumen
\n<\/span><\/strong>Aqu\u00ed, se presenta<\/span><\/span> e investigamos<\/span> las<\/span> alteraciones gen\u00f3micas<\/span> de<\/span> dos<\/span> nuevos<\/span> casos de<\/span> linfoma no Hodgkin<\/span> (LNH<\/span>) en los ni\u00f1os con s\u00edndrome de<\/span> Williams-<\/span>Beuren (WBS<\/span>), una enfermedad multisist\u00e9mica<\/span> causada por<\/span> 7q11.23<\/span> supresi\u00f3n<\/span> hemicigotos<\/span>. Adem\u00e1s,<\/span> se presenta el caso<\/span> de un ni\u00f1o con<\/span> NHL<\/span> y una deleci\u00f3n<\/span> 7q11.23<\/span> som\u00e1tica.<\/span> Aunque<\/span> la regi\u00f3n cr\u00edtica<\/span> WBS<\/span> a\u00fan no ha<\/span> sido identificado como<\/span> un locus de susceptibilidad<\/span> en<\/span> NHL<\/span>, alberga un n\u00famero<\/span> de genes implicados en<\/span> la reparaci\u00f3n del ADN<\/span>. La alta proporci\u00f3n de<\/span> LNH infantil<\/span> reportados en<\/span> WBS<\/span> es intrigante.<\/span> Por lo tanto<\/span>, el papel de la haploinsuficiencia<\/span> de<\/span> genes<\/span> situados en<\/span> 7q11.23<\/span> en<\/span> lymphomagenesis<\/span> merece ser<\/span> investigado<\/span>.<\/span><\/p>\n

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/4.0<\/a>),<\/p>\n

Corresponding author: David Guenat david.guenat@univ-fcomte.fr<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

JOURNAL HEMATOLOY AND ONCOLOGY 2014, 7:82\u00a0(NOVIEMBRE) Carta al Editor Supresiones Constitucionales y som\u00e1ticas del s\u00edndrome de la regi\u00f3n cr\u00edtica de Williams-Beuren en el linfoma no Hodgkin. Resumen Aqu\u00ed, se presenta e investigamos las alteraciones gen\u00f3micas de dos nuevos casos de linfoma no Hodgkin (LNH) en los ni\u00f1os con s\u00edndrome de Williams-Beuren (WBS), una enfermedad multisist\u00e9mica […]<\/p>\n","protected":false},"author":176,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[8],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/posts\/2483"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/users\/176"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/comments?post=2483"}],"version-history":[{"count":0,"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/posts\/2483\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/media?parent=2483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/categories?post=2483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/inorbib\/wp-json\/wp\/v2\/tags?post=2483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}