{"id":1432,"date":"2013-11-17T18:34:51","date_gmt":"2013-11-17T22:34:51","guid":{"rendered":"http:\/\/blogviejo.sld.cu\/oserranob\/?p=1432"},"modified":"2013-11-17T18:34:51","modified_gmt":"2013-11-17T22:34:51","slug":"defecto-enzimatico-y-enfermedades-neurodegenerativas","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2013\/11\/17\/defecto-enzimatico-y-enfermedades-neurodegenerativas\/","title":{"rendered":"Defecto enzim\u00e1tico y enfermedades neurodegenerativas"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2013\/11\/journal.pone_.0074967.g004.png\"><img loading=\"lazy\" class=\"alignright size-thumbnail wp-image-1499\" style=\"border: 1px solid black;margin: 5px\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2013\/11\/journal.pone_.0074967.g004-150x107.png\" alt=\"\" width=\"120\" height=\"86\" \/><\/a>Estudios en animales de laboratorio sugieren que las mutaciones en la enzima <a title=\"Informaci\u00f3n sobre el gen\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/gene\/3251\" target=\"_blank\"><strong>HPRT<\/strong><\/a> afectan m\u00faltiples v\u00edas metab\u00f3licas en las neuronas, algunas de las cuales han sido descritas en la <a title=\"Informaci\u00f3n sobre la enfermedad\" href=\"http:\/\/omim.org\/entry\/104300\" target=\"_blank\"><strong>enfermedad de Alzheimer <\/strong><\/a>y la <a title=\"Informaci\u00f3n sobre la enfermedad\" href=\"http:\/\/omim.org\/entry\/143100\" target=\"_blank\"><strong>corea de Huntington<\/strong><\/a>. Acceda al art\u00edculo de <em>Kang TH, Park Y, Bader JS, Friedmann T. <a title=\"Texto completo en ingl\u00e9s\" href=\"http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0074967\" target=\"_blank\"><strong>The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation<\/strong><\/a>. PLoS ONE 2013;8(10):e74967<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estudios en animales de laboratorio sugieren que las mutaciones en la enzima HPRT afectan m\u00faltiples v\u00edas metab\u00f3licas en las neuronas, algunas de las cuales han sido descritas en la enfermedad de Alzheimer y la corea de Huntington. Acceda al art\u00edculo de Kang TH, Park Y, Bader JS, Friedmann T. The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,25,26,29],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/1432"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=1432"}],"version-history":[{"count":0,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/1432\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=1432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=1432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=1432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}