{"id":1749,"date":"2014-06-02T04:47:43","date_gmt":"2014-06-02T04:47:43","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=1749"},"modified":"2014-06-02T23:41:11","modified_gmt":"2014-06-02T23:41:11","slug":"mecanismos-de-resistencia-a-ibrutinib","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2014\/06\/02\/mecanismos-de-resistencia-a-ibrutinib\/","title":{"rendered":"Mecanismos de resistencia a Ibrutinib"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2014\/06\/2014-06-02-nejmoa1400029_f2.jpeg\"><img loading=\"lazy\" class=\"alignleft  wp-image-1765\" style=\"border: 1px solid black;margin: 5px\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2014\/06\/2014-06-02-nejmoa1400029_f2.jpeg\" alt=\"\" width=\"120\" height=\"63\" \/><\/a>La secuenciaci\u00f3n del exoma completo revel\u00f3 las mutaciones que afectan el sitio de uni\u00f3n al ibrutinib, medicamento empleado en el tratamiento de la leucemia linfoc\u00edtica cr\u00f3nica. La resistencia al f\u00e1rmaco tambi\u00e9nd depende de cambios en la enzima PLC2, seg\u00fan Woyach JA, Furman RR, Liu TM, Ozer HG, Zapatka M, Ruppert AS, <em>et al<\/em>. <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1400029#t=article\" target=\"_blank\">Resistance Mechanisms for the Bruton&#8217;s Tyrosine Kinase Inhibitor Ibrutinib<\/a>. N Engl J Med May 28, 2014; DOI: 10.1056\/NEJMoa1400029.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La secuenciaci\u00f3n del exoma completo revel\u00f3 las mutaciones que afectan el sitio de uni\u00f3n al ibrutinib, medicamento empleado en el tratamiento de la leucemia linfoc\u00edtica cr\u00f3nica. La resistencia al f\u00e1rmaco tambi\u00e9nd depende de cambios en la enzima PLC2, seg\u00fan Woyach JA, Furman RR, Liu TM, Ozer HG, Zapatka M, Ruppert AS, et al. Resistance Mechanisms [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,15,19],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/1749"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=1749"}],"version-history":[{"count":6,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/1749\/revisions"}],"predecessor-version":[{"id":1764,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/1749\/revisions\/1764"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=1749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=1749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=1749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}