{"id":3326,"date":"2016-08-15T18:14:00","date_gmt":"2016-08-15T18:14:00","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=3326"},"modified":"2016-08-15T18:55:46","modified_gmt":"2016-08-15T18:55:46","slug":"identifican-causa-de-resistencia-en-melanoma","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2016\/08\/15\/identifican-causa-de-resistencia-en-melanoma\/","title":{"rendered":"Identifican causa de resistencia en melanoma"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2016\/08\/2016-08-15-melanoma.jpg\"><img loading=\"lazy\" class=\"alignleft size-full wp-image-3354\" style=\"border-width: 1px;margin: 5px\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2016\/08\/2016-08-15-melanoma.jpg\" alt=\"2016 08 15 melanoma\" width=\"85\" height=\"78\" \/><\/a>La secuenciaci\u00f3n del exoma revel\u00f3 que las mutaciones en las prote\u00ednas <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/gene\/10735\" target=\"_blank\">STAG2<\/a> y <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/gene\/10734\" target=\"_blank\">STAG3<\/a> son responsables de resistencia a la inhibici\u00f3n de <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/gene\/673\" target=\"_blank\">BRAF<\/a> en pacientes con <a title=\"Informaci\u00f3n sobre la enfermedad en OMIM\" href=\"http:\/\/omim.org\/entry\/155600\" target=\"_blank\">melanoma<\/a>. As\u00ed se publica en Shen CH, Kim SH, Trousil S, Frederick DT, Piris A, Yuan P, <em>et al<\/em>. <a title=\"Texto completo en ingl\u00e9s\" href=\"http:\/\/www.nature.com\/nm\/journal\/vaop\/ncurrent\/full\/nm.4155.html\" target=\"_blank\">Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma<\/a>. Nature Medicine 2016; doi:10.1038\/nm.4155.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La secuenciaci\u00f3n del exoma revel\u00f3 que las mutaciones en las prote\u00ednas STAG2 y STAG3 son responsables de resistencia a la inhibici\u00f3n de BRAF en pacientes con melanoma. As\u00ed se publica en Shen CH, Kim SH, Trousil S, Frederick DT, Piris A, Yuan P, et al. Loss of cohesin complex components STAG2 or STAG3 confers resistance [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,19,23,29,32],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3326"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=3326"}],"version-history":[{"count":3,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3326\/revisions"}],"predecessor-version":[{"id":3356,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3326\/revisions\/3356"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=3326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=3326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=3326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}