{"id":3865,"date":"2017-07-23T04:15:53","date_gmt":"2017-07-23T04:15:53","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=3865"},"modified":"2017-07-23T04:39:45","modified_gmt":"2017-07-23T04:39:45","slug":"genomica-de-la-osteoartritis-y-el-dolor-asociado","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2017\/07\/23\/genomica-de-la-osteoartritis-y-el-dolor-asociado\/","title":{"rendered":"Gen\u00f3mica de la osteoartritis y el dolor asociado"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2017\/07\/2017-07-22-OA.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-3885 size-full\" style=\"border-width: 1px;margin: 5px\" title=\"(c) Kuttapitiya A et al. Annals of the Rheumatic Diseases 2017\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2017\/07\/2017-07-22-OA.jpg\" alt=\"2017 07 22 OA\" width=\"85\" height=\"73\" \/><\/a>Con la utilizaci\u00f3n de microarreglos en pacientes con <a title=\"Informaci\u00f3n sobre la enfermedad en OMIM\" href=\"http:\/\/omim.org\/entry\/165720\" target=\"_blank\">osteoartritis<\/a> avanzada que requer\u00edan reemplazo total de rodilla, se encontr\u00f3 la expresi\u00f3n aumentada de 218 genes, entre ellos <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/11075\" target=\"_blank\">stathmin 2<\/a>, <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/7060\" target=\"_blank\">thrombospondin 4<\/a> y <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/4322\" target=\"_blank\">matrix metalloproteinase 13<\/a>. La activaci\u00f3n de mol\u00e9culas de se\u00f1alizaci\u00f3n Wnt\/Notch\/catenina\/quimiocina puede explicar la habitual presencia de dolor en estos enfermos, de acuerdo con Kuttapitiya A, Assi L, Laing K, Hing C, Mitchell P, Whitley G, <em>et al<\/em>. <a title=\"Texto completo en ingl\u00e9s\" href=\"http:\/\/ard.bmj.com\/content\/early\/2017\/07\/12\/annrheumdis-2017-211396\" target=\"_blank\">Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation<\/a>. Annals of the Rheumatic Diseases 2017; doi: 10.1136\/annrheumdis-2017-211396.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Con la utilizaci\u00f3n de microarreglos en pacientes con osteoartritis avanzada que requer\u00edan reemplazo total de rodilla, se encontr\u00f3 la expresi\u00f3n aumentada de 218 genes, entre ellos stathmin 2, thrombospondin 4 y matrix metalloproteinase 13. La activaci\u00f3n de mol\u00e9culas de se\u00f1alizaci\u00f3n Wnt\/Notch\/catenina\/quimiocina puede explicar la habitual presencia de dolor en estos enfermos, de acuerdo con Kuttapitiya [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,29,39],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3865"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=3865"}],"version-history":[{"count":6,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3865\/revisions"}],"predecessor-version":[{"id":3901,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/3865\/revisions\/3901"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=3865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=3865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=3865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}