{"id":4027,"date":"2017-10-22T02:22:08","date_gmt":"2017-10-22T02:22:08","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=4027"},"modified":"2017-10-23T18:55:01","modified_gmt":"2017-10-23T18:55:01","slug":"corrigen-inmunodeficiencia-por-edicion-del-genoma-en-modelo-animal","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2017\/10\/22\/corrigen-inmunodeficiencia-por-edicion-del-genoma-en-modelo-animal\/","title":{"rendered":"Corrigen inmunodeficiencia por edici\u00f3n del genoma en modelo animal"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2017\/10\/2017-10-22-stem-cells.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-4052 size-full\" style=\"border-width: 1px;margin: 5px\" title=\"(c) Schiroli G, et al. Science Translational Medicine 2017\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2017\/10\/2017-10-22-stem-cells.jpg\" alt=\"2017 10 22 stem cells\" width=\"85\" height=\"71\" \/><\/a>Un modelo de\u00a0<a href=\"http:\/\/omim.org\/entry\/300400\">inmunodeficiencia severa ligada al X<\/a> (<a href=\"http:\/\/omim.org\/entry\/300400\">SCID-X1<\/a>) en ratones con un sistema inmune humanizado fue tratado por medio de la edici\u00f3n del genoma con CRISPR\/Cas9 para la correcci\u00f3n del gen <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/3561\">IL2RG<\/a>. Se estandarizaron los procedimientos que permiten la traducci\u00f3n cl\u00ednica para esa y otras enfermedades. As\u00ed se presenta en Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, <em>et al<\/em>. <a title=\"Texto completo en ingl\u00e9s\" href=\"http:\/\/stm.sciencemag.org\/content\/9\/411\/eaan0820.full\" target=\"_blank\">Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1<\/a>. Science Translational Medicine 11 Oct 2017;9(411):eaan0820.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un modelo de\u00a0inmunodeficiencia severa ligada al X (SCID-X1) en ratones con un sistema inmune humanizado fue tratado por medio de la edici\u00f3n del genoma con CRISPR\/Cas9 para la correcci\u00f3n del gen IL2RG. Se estandarizaron los procedimientos que permiten la traducci\u00f3n cl\u00ednica para esa y otras enfermedades. As\u00ed se presenta en Schiroli G, Ferrari S, Conway [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[14,23,29],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4027"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=4027"}],"version-history":[{"count":4,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4027\/revisions"}],"predecessor-version":[{"id":4059,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4027\/revisions\/4059"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=4027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=4027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=4027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}