{"id":4585,"date":"2020-02-11T04:51:14","date_gmt":"2020-02-11T04:51:14","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=4585"},"modified":"2020-02-17T18:57:14","modified_gmt":"2020-02-17T18:57:14","slug":"primeros-cambios-moleculares-en-cancer-de-mama-brca2","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2020\/02\/11\/primeros-cambios-moleculares-en-cancer-de-mama-brca2\/","title":{"rendered":"Primeros cambios moleculares en c\u00e1ncer de mama BRCA2+"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2020\/02\/2020-02-12-BRCA2.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-4604 size-full\" style=\"border-width: 1px;margin: 5px\" title=\"(c) Karaayvaz-Yildirim M, et al. Science Advances 2020\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2020\/02\/2020-02-12-BRCA2.jpg\" alt=\"2020 02 12 BRCA2\" width=\"85\" height=\"98\" \/><\/a>Las tecnolog\u00edas de secuenciaci\u00f3n han revelado la existencia de variantes del n\u00famero de copias y reducci\u00f3n en las respuestas apopt\u00f3tica y de control de la replicaci\u00f3n, en las c\u00e9lulas portadoras de mutaciones en el gen <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/675\" target=\"_blank\">BRCA2<\/a>. Ello abre nuevas oportunidades para la evaluaci\u00f3n del riesgo, de acuerdo con Karaayvaz-Yildirim M, Silberman RE, Langenbucher A, Saladi SV, Ross KN, Zarcaro E, <em>et al<\/em>. <a title=\"Texto completo en ingl\u00e9s\" href=\"https:\/\/advances.sciencemag.org\/content\/6\/5\/eaay2611\" target=\"_blank\">Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers<\/a>. Science Advances 2020;6(5):eaay2611.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Las tecnolog\u00edas de secuenciaci\u00f3n han revelado la existencia de variantes del n\u00famero de copias y reducci\u00f3n en las respuestas apopt\u00f3tica y de control de la replicaci\u00f3n, en las c\u00e9lulas portadoras de mutaciones en el gen BRCA2. Ello abre nuevas oportunidades para la evaluaci\u00f3n del riesgo, de acuerdo con Karaayvaz-Yildirim M, Silberman RE, Langenbucher A, Saladi [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[11],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4585"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=4585"}],"version-history":[{"count":5,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4585\/revisions"}],"predecessor-version":[{"id":4620,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4585\/revisions\/4620"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=4585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=4585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=4585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}