{"id":4752,"date":"2020-07-31T18:02:08","date_gmt":"2020-07-31T18:02:08","guid":{"rendered":"http:\/\/blogs.sld.cu\/oserranob\/?p=4752"},"modified":"2020-07-31T18:02:08","modified_gmt":"2020-07-31T18:02:08","slug":"variantes-geneticas-de-tlr7-se-asocian-a-gravedad-en-covid-19","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2020\/07\/31\/variantes-geneticas-de-tlr7-se-asocian-a-gravedad-en-covid-19\/","title":{"rendered":"Variantes gen\u00e9ticas de TLR7 se asocian a gravedad en COVID-19"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2020\/07\/TLR7.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-4753 size-full\" style=\"border-width: 1px;margin: 5px\" title=\"(c) van der Made CI, et al. JAMA, 2020\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2020\/07\/TLR7.jpg\" alt=\"TLR7\" width=\"85\" height=\"99\" \/><\/a>La secuenciaci\u00f3n del exoma completo identific\u00f3 variantes afuncionales del receptor <a title=\"Informaci\u00f3n sobre el gen en Gene\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/51284\" target=\"_blank\">TLR7<\/a>, en pacientes j\u00f3venes con formas graves de la <a title=\"Informaci\u00f3n sobre COVID-19 en Infomed\" href=\"https:\/\/temas.sld.cu\/coronavirus\/covid-19\/\" target=\"_blank\">COVID-19<\/a>, lo que puede explicar defectos inmunitarios que comprometen la producci\u00f3n de interferones. El reporte aparece en van der Made CI, Simons A, Schuurs-Hoeijmakers J, van den Heuvel G, Mantere T, Kersten S, <em>et al<\/em>. <a title=\"Texto completo en ingl\u00e9s\" href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2768926\" target=\"_blank\">Presence of Genetic Variants Among Young Men With Severe COVID-19<\/a>. JAMA, 2020; doi:10.1001\/jama.2020.13719.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La secuenciaci\u00f3n del exoma completo identific\u00f3 variantes afuncionales del receptor TLR7, en pacientes j\u00f3venes con formas graves de la COVID-19, lo que puede explicar defectos inmunitarios que comprometen la producci\u00f3n de interferones. El reporte aparece en van der Made CI, Simons A, Schuurs-Hoeijmakers J, van den Heuvel G, Mantere T, Kersten S, et al. Presence [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,28,29],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4752"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=4752"}],"version-history":[{"count":1,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4752\/revisions"}],"predecessor-version":[{"id":4754,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/4752\/revisions\/4754"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=4752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=4752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=4752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}