{"id":5719,"date":"2023-10-11T17:54:12","date_gmt":"2023-10-11T17:54:12","guid":{"rendered":"https:\/\/blogs.sld.cu\/oserranob\/?p=5719"},"modified":"2023-10-12T04:59:19","modified_gmt":"2023-10-12T04:59:19","slug":"prosiguen-ensayos-para-tratar-sicklemia-con-edicion-del-genoma","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2023\/10\/11\/prosiguen-ensayos-para-tratar-sicklemia-con-edicion-del-genoma\/","title":{"rendered":"Prosiguen ensayos para tratar sicklemia con edici\u00f3n del genoma"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2023\/10\/2023-CRISPRCas.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-5767 size-full\" title=\"(c) Sharma A, et al. N Engl J Med, 2023.\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2023\/10\/2023-CRISPRCas.jpg\" alt=\"\" width=\"150\" height=\"85\" \/><\/a>La disrupci\u00f3n de los promotores de los genes <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/3047\">HBG1<\/a> y <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/3048\">HBG2<\/a>, por medio de CRISPR-Cas9, increment\u00f3 significativamente los niveles de hemoglobina fetal en tres pacientes con <a href=\"https:\/\/omim.org\/entry\/603903\">anemia de c\u00e9lulas falciformes<\/a>, quienes presentaron menos s\u00edntomas de la enfermedad. El <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04443907\">ensayo cl\u00ednico<\/a> es reportado en Sharma A, Boelens JJ, Cancio M, Hankins JS, Bhad P, Azizy M, et al. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2215643\">CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease<\/a>. N Engl J Med 2023;389:820-832.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La disrupci\u00f3n de los promotores de los genes HBG1 y HBG2, por medio de CRISPR-Cas9, increment\u00f3 significativamente los niveles de hemoglobina fetal en tres pacientes con anemia de c\u00e9lulas falciformes, quienes presentaron menos s\u00edntomas de la enfermedad. El ensayo cl\u00ednico es reportado en Sharma A, Boelens JJ, Cancio M, Hankins JS, Bhad P, Azizy M, [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[44,23,32],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5719"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=5719"}],"version-history":[{"count":4,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5719\/revisions"}],"predecessor-version":[{"id":5742,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5719\/revisions\/5742"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=5719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=5719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=5719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}