{"id":5804,"date":"2023-12-17T04:50:16","date_gmt":"2023-12-17T04:50:16","guid":{"rendered":"https:\/\/blogs.sld.cu\/oserranob\/?p=5804"},"modified":"2023-12-18T18:31:50","modified_gmt":"2023-12-18T18:31:50","slug":"advierten-riesgo-de-malignidad-en-ensayos-de-terapia-genica","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/oserranob\/2023\/12\/17\/advierten-riesgo-de-malignidad-en-ensayos-de-terapia-genica\/","title":{"rendered":"Advierten riesgo de malignidad en ensayos de terapia g\u00e9nica"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2023\/12\/231217_GeneTher.jpg\"><img loading=\"lazy\" class=\"alignleft wp-image-5839 size-full\" title=\"(c) Chapman MS et al. Nature Medicine, 2023.\" src=\"https:\/\/blogs.sld.cu\/oserranob\/files\/2023\/12\/231217_GeneTher.jpg\" alt=\"\" width=\"150\" height=\"85\" \/><\/a>La secuenciaci\u00f3n del genoma completo en c\u00e9lulas madres hematopoy\u00e9ticas ha revelado un incremento de mutaciones de riesgo potencial para neoplasias mieloides o hematopoyesis clonal. Las implicaciones del hallazgo son comentadas en Chapman MS, Cull AH, Ciuculescu MF, Esrick EB, Mitchell E, Jung H, et al. <a href=\"https:\/\/www.nature.com\/articles\/s41591-023-02636-6\">Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease<\/a>. Nature Medicine, 2023;29:3175\u20133183.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La secuenciaci\u00f3n del genoma completo en c\u00e9lulas madres hematopoy\u00e9ticas ha revelado un incremento de mutaciones de riesgo potencial para neoplasias mieloides o hematopoyesis clonal. Las implicaciones del hallazgo son comentadas en Chapman MS, Cull AH, Ciuculescu MF, Esrick EB, Mitchell E, Jung H, et al. Clonal selection of hematopoietic stem cells after gene therapy for [&hellip;]<\/p>\n","protected":false},"author":125,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[11,44],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5804"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/users\/125"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/comments?post=5804"}],"version-history":[{"count":3,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5804\/revisions"}],"predecessor-version":[{"id":5841,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/posts\/5804\/revisions\/5841"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/media?parent=5804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/categories?post=5804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/oserranob\/wp-json\/wp\/v2\/tags?post=5804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}