{"id":780,"date":"2020-01-16T03:44:59","date_gmt":"2020-01-16T03:44:59","guid":{"rendered":"http:\/\/blogs.sld.cu\/reumatologia\/?p=780"},"modified":"2020-01-16T03:56:29","modified_gmt":"2020-01-16T03:56:29","slug":"recomendaciones-ser-sobre-la-utilizacion-de-farmacos-biologicos-en-el-sindrome-de-sjogren-primario","status":"publish","type":"post","link":"https:\/\/blogs.sld.cu\/reumatologia\/2020\/01\/16\/recomendaciones-ser-sobre-la-utilizacion-de-farmacos-biologicos-en-el-sindrome-de-sjogren-primario\/","title":{"rendered":"Recomendaciones SER sobre la utilizaci\u00f3n de f\u00e1rmacos biol\u00f3gicos en el s\u00edndrome de Sj\u00f6gren primario"},"content":{"rendered":"
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Reumatolog\u00eda cl\u00ednica<\/div>\n
Vol. 15. N\u00fam. 6.<\/span><\/a><\/p>\n
P\u00e1ginas 315-326<\/span> (Noviembre – Diciembre 2019)<\/span><\/div>\n<\/div>\n
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Read this article in English<\/a><\/div>\n
Descargar PDF<\/a><\/div>\n<\/div>\n<\/div>\n
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Art\u00edculo especial<\/span><\/div>\n<\/section>\n
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DOI: 10.1016\/j.reuma.2018.10.014<\/div>\n<\/div>\n
<\/div>\n<\/section>\n
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Recomendaciones SER sobre la utilizaci\u00f3n de f\u00e1rmacos biol\u00f3gicos en el s\u00edndrome de Sj\u00f6gren primario<\/div>\n<\/section>\n
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SER recommendations on the use of biological drugs in primary Sj\u00f6gren’s syndrome<\/div>\n<\/div>\n<\/section>\n
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Jos\u00e9 Luis Andr\u00e9u S\u00e1nchez<\/span>a<\/span><\/a>,<\/span><\/span><\/p>\n
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, M\u00f3nica Fern\u00e1ndez Castro<\/span>b<\/span><\/a><\/span>, Petra D\u00edaz del Campo Fontecha<\/span>c<\/span><\/a><\/span>, H\u00e9ctor Corominas<\/span>d<\/span><\/a><\/span>, Francisco Javier Narv\u00e1ez Garc\u00eda<\/span>e<\/span><\/a><\/span>, Jos\u00e9 Rosas G\u00f3mez de Salazar<\/span>f<\/span><\/a><\/span>, \u00cd\u00f1igo Rua-Figueroa<\/span>g<\/span><\/a><\/span>, Miguel \u00c1ngel Abad Hern\u00e1ndez<\/span>h<\/span><\/a><\/span>, Mar\u00eda Noelia \u00c1lvarez Rivas<\/span>i<\/span><\/a><\/span>, Javier del Pino Montes<\/span>j<\/span><\/a><\/span>, F\u00e9lix Manuel Francisco Hern\u00e1ndez<\/span>g<\/span><\/a><\/span>, Mar\u00eda \u00c1ngeles Gantes Pedraza<\/span>h<\/span><\/a><\/span>, Mart\u00edn Gerardo Greco Merino<\/span>g<\/span><\/a><\/span>, Mar\u00eda Vanesa Hern\u00e1ndez<\/span>k<\/span><\/a><\/span>, Mar\u00eda Victoria Navarro Comp\u00e1n<\/span>l<\/span><\/a><\/span>, Juan Alberto Paz Solarte<\/span>m<\/span><\/a><\/span>, Fredeswinda I. Romero Bueno<\/span>n<\/span><\/a><\/span>, Hye Sang Park<\/span>o<\/span><\/a><\/span>, Francisca Sivera Mascar\u00f3<\/span>p<\/span><\/a><\/span><\/p>\n

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<\/a>a <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Espa\u00f1a<\/span><\/div>\n
<\/a>b <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario Infanta Sof\u00eda, San Sebasti\u00e1n de los Reyes, Madrid, Espa\u00f1a<\/span><\/div>\n
<\/a>c <\/span>Unidad de Investigaci\u00f3n, Sociedad Espa\u00f1ola de Reumatolog\u00eda, Madrid, Espa\u00f1a<\/span><\/div>\n
<\/a>d <\/span>Unitat Territorial de Reumatolog\u00eda, Hospital Universitari de la Santa Creu i Sant Pau y Hospital Dos de Maig, Barcelona, Espa\u00f1a<\/span><\/div>\n
<\/a>e <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario de Bellvitge, L\u2019Hospitalet de Llobregat, Espa\u00f1a<\/span><\/div>\n
<\/a>f <\/span>Servicio de Reumatolog\u00eda, Hospital Marina Baixa, La Vila Joiosa, Alicante, Espa\u00f1a<\/span><\/div>\n
<\/a>g <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario Dr. Negr\u00edn, Las Palmas, Espa\u00f1a<\/span><\/div>\n
<\/a>h <\/span>Servicio de Reumatolog\u00eda. Hospital Virgen del Puerto, Plasencia, Espa\u00f1a<\/span><\/div>\n
<\/a>i <\/span>Servicio de Reumatolog\u00eda, Hospital Lucus Augusti Lugo, Lugo, Espa\u00f1a<\/span><\/div>\n
<\/a>j <\/span>Servicio de Reumatolog\u00eda. Hospital Universitario de Salamanca, Salamanca, Espa\u00f1a<\/span><\/div>\n
<\/a>k <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Espa\u00f1a<\/span><\/div>\n
<\/a>l <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario La Paz, Madrid, Espa\u00f1a<\/span><\/div>\n
<\/a>m <\/span>Servicio de Reumatolog\u00eda, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Espa\u00f1a<\/span><\/div>\n
<\/a>n <\/span>Servicio de Reumatolog\u00eda, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Espa\u00f1a<\/span><\/div>\n
<\/a>o <\/span>Servicio de Reumatolog\u00eda, Hospital de la Santa Creu i Sant Pau, Barcelona, Espa\u00f1a<\/span><\/div>\n
<\/a>p <\/span>Servicio de Reumatolog\u00eda, Hospital Universitario de Elda, Elda, Alicante, Espa\u00f1a<\/span><\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

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Resumen<\/h3>\n
Objetivo<\/span><\/span><\/span><\/p>\n

Elaborar recomendaciones SER sobre el uso de agentes biol\u00f3gicos en el s\u00edndrome de Sj\u00f6gren primario (SSp).<\/p>\n

M\u00e9todos<\/span><\/span><\/span><\/p>\n

Se identificaron preguntas cl\u00ednicas de investigaci\u00f3n relevantes sobre el uso de agentes biol\u00f3gicos en el SSp. Las preguntas cl\u00ednicas se reformularon en 4preguntas PICO. Se dise\u00f1\u00f3 una estrategia de b\u00fasqueda y se realiz\u00f3 una revisi\u00f3n de la evidencia cient\u00edfica de estudios publicados hasta mayo de 2017. Se revis\u00f3 sistem\u00e1ticamente la evidencia cient\u00edfica disponible. Se evalu\u00f3 el nivel global de la evidencia cient\u00edfica utilizando los niveles de evidencia del SIGN. Tras ello, se formularon recomendaciones espec\u00edficas.<\/p>\n

Resultados<\/span><\/span><\/span><\/p>\n

Se recomienda rituximab como el f\u00e1rmaco biol\u00f3gico de elecci\u00f3n para las manifestaciones extraglandulares refractarias al tratamiento convencional. Se desaconseja el uso de agentes anti-TNF. La evidencia cient\u00edfica es escasa con belimumab y abatacept, por lo que deber\u00edan considerarse solamente en los casos resistentes a rituximab.<\/p>\n

Conclusiones<\/span><\/span><\/span><\/p>\n

El rituximab es el f\u00e1rmaco biol\u00f3gico de elecci\u00f3n en las manifestaciones graves extraglandulares del SSp. Belimumab o abatacept podr\u00edan ser de utilidad en casos seleccionados.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/article>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Reumatolog\u00eda cl\u00ednica Vol. 15. N\u00fam. 6. P\u00e1ginas 315-326 (Noviembre – Diciembre 2019) Read this article in English Descargar PDF Art\u00edculo especial DOI: 10.1016\/j.reuma.2018.10.014 Recomendaciones SER sobre la utilizaci\u00f3n de f\u00e1rmacos biol\u00f3gicos en el s\u00edndrome de Sj\u00f6gren primario SER recommendations on the use of biological drugs in primary Sj\u00f6gren’s syndrome Jos\u00e9 Luis Andr\u00e9u S\u00e1ncheza, , M\u00f3nica […]<\/p>\n","protected":false},"author":140,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[69,9],"tags":[30,27,18,158],"_links":{"self":[{"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/posts\/780"}],"collection":[{"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/users\/140"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/comments?post=780"}],"version-history":[{"count":3,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/posts\/780\/revisions"}],"predecessor-version":[{"id":785,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/posts\/780\/revisions\/785"}],"wp:attachment":[{"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/media?parent=780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/categories?post=780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sld.cu\/reumatologia\/wp-json\/wp\/v2\/tags?post=780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}