Un tipo de macrófago profibrótico presente en la covid-19 y el carcinoma pulmonar, es parte de los hallazgos del nuevo Atlas Celular del Pulmón Humano, el cual es presentado en Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, et al. An integrated cell atlas of the lung in health and disease. Nature Medicine, 2023.
Filed under Cáncer, covid-19, Diagnóstico by on . Comment.
– Modulation and personalization of therapy after acute coronary syndromes: the road to precision
– Precision Medicine in Oral Health and Diseases: A Systematic Review
– Hope in the era of precision oncology: a qualitative study of informal caregivers’ experiences
– Translating Precision Health for Pediatrics: A Scoping Review
– Reconceptualising precision public health
Filed under Cáncer, Cardiopatías, Estomatología, Medicina personalizada by on . Comment.
Un conjunto de 36 proteínas plasmáticas se asociaron con riesgo inminente de diagnóstico de cáncer de pulmón. Entre ellas, factores de crecimiento (HGF, IGFBP-1, IGFP-2), citocinas (TNFRSF6B, TNFRSF13B) y quimiocinas (CXL17), según The Lung Cancer Cohort Consortium. The blood proteome of imminent lung cancer diagnosis. Nature Communications, 2023;14:3042.
Filed under Cáncer, Diagnóstico, Proteómica by on . Comment.
– Genomics in Clinical Practice
– Personalized medicine is having its day
– Genomic–transcriptomic evolution in lung cancer and metastasis
– Genomic profiling to expand precision cancer medicine in the real world: The ROME trial
– On the gene expression landscape of cancer
– Precision Medicine in Type 1 Diabetes
– 2023 Watch List: Top 10 Precision Medicine Technologies and Issues
Filed under Cáncer, Genómica, Medicina personalizada, Transcriptómica by on . Comment.
– Blood-Based mRNA Tests as Emerging Diagnostic Tools for Personalised Medicine in Breast Cancer
– Reclassification of the Etiology of Infant Mortality With Whole-Genome Sequencing
– The Pathogenic Diagnosis in Pediatric Diabetology: Next Generation Sequencing and Precision Therapy
– Systematic assessment of prognostic molecular features across cancers
– Landscape of pathogenic mutations in premature ovarian insufficiency
– Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children’s Oncology Group
– Exome/Genome Sequencing in Undiagnosed Syndromes
– Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review
Filed under Cáncer, Cardiopatías, Diagnóstico by on . Comment.
El uso de ensayos diagnósticos para el uso efectivo y seguro de la terapia oncológica es un área en expansión, a partir del uso de las tecnologías ómicas. El tema es abordado en Schilsky RL, Longo DL. Closing the Gap in Cancer Genomic Testing. N Engl J Med, 2022; 387:2107-2110.
Filed under Cáncer, Diagnóstico by on . Comment.
– Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study. BMJ 2022;379:e071707.
– Biobanking as a Tool for Genomic Research: From Allele Frequencies to Cross-Ancestry Association Studies. J. Pers. Med. 2022;12(12), 2040.
Filed under Cáncer, Diagnóstico, Genómica by on . Comment.
La presencia de hongos en muestras diversas de 17 tipos de tumores malignos, su influencia en las respuestas inmunes y el sinergismo con las bacterias locales, podrían significar nuevos caminos en la patogenia y la atención al cáncer. Así se comenta en Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell, 2022;185(20):3789-3806.e17.
Filed under Cáncer, Microbioma by on . Comment.
– Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell, 2022;40(9):999-1009.e6.
– Clinical Utility of Universal Germline Genetic Testing for Patients With Breast Cancer. JAMA Netw Open. 2022;5(9):e2232787.
Filed under Cáncer, Diagnóstico, Transcriptómica by on . Comment.
La presencia de segmentos mitocondriales en el ADN nuclear fue detectada tanto en recién nacidos como en tumores malignos, con al menos una probable asociación causal en un tipo de liposarcoma. Los hallazgos son presentados en Wei W, Schon KR, Elgar G, Orioli A, Tanguy M, Giess A, et al. Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes. Nature, 2022;611:105–114.
Filed under Cáncer, Diagnóstico, Genómica by on . Comment.
Disponible la versión digital del libro "Cuba indígena hoy: rostros y ADN"
(Nota en CubaDebate)
