Cáncer

Ómicas y medicina de precisión impactan en oncohematología

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– Developing a classification of hematologic neoplasms in the era of precision medicine. Blood, 2022;140(11):1193–1199.
– Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia. Blood, 2022; blood.2022015853.
– Single Cell Genomics – a new chapter in how technological advances propel Hemato-Oncology. Blood. 2022 Sep 14;blood.2022017361.
– Whole-genome and transcriptome analysis enhances precision cancer treatment options. Annals of Oncology, September 2022;33(9):939-949.

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Genómica unicelular en la genética humana

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Las aplicaciones de la genómica unicelular (del inglés single-cell genomics) en el diagnóstico y tratamiento de las enfermedades genéticas, el cáncer, la anotación del genoma no codificante y la definición de prioridades para las variantes, son discutidas en Sreenivasan VKA, Balachandran S, Spielmann M. The role of single-cell genomics in human genetics. J Med Genet. 2022 Sep;59(9):827-839.

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Genómica en el cáncer: pulmón, neoplasias linfoides

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– Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer. Cancer Res, 2022;82(16):2838–2847.
– Changes in Circulating Tumor DNA Reflect Clinical Benefit Across Multiple Studies of Patients With Non–Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors. JCO Precision Oncology, 2022;6:e2100372.
– Genomic Profiling for Clinical Decision Making in Lymphoid Neoplasms. Blood. 2022 Aug 24; doi: 10.1182/blood.2022015854.

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Otras aplicaciones terapéuticas de la edición del genoma

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– CRISPR based therapeutics: a new paradigm in cancer precision medicine
– CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer
– Genome Editing of Pluripotent Stem Cells for Adoptive and Regenerative Cell Therapies
– CRISPR Genome Editing: Into the Second Decade

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Ómicas y cáncer: metástasis, asociaciones tumorales, docencia

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– Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
– Clinical Utility of Genomic Testing in Cancer Care
– Biología de sistemas y computacional en cáncer: de lo básico a la próxima frontera
– Genetic and genomic learning needs of oncologists and oncology nurses in the era of precision medicine: a scoping review
– Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes
– Single whole genome sequencing analysis blazes the trail for precision medicine

Filed under Biología de sistemas, Cáncer, Diagnóstico, Genómica, Medicina personalizada by on . Comment. #

Novedades sobre bases de datos ómicos

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– GMrepo v2: a curated human gut microbiome database with special focus on disease markers and cross-dataset comparison
– OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer
– mBodyMap: a curated database for microbes across human body and their associations with health and diseases
– Genomicus in 2022: comparative tools for thousands of genomes and reconstructed ancestors

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Variantes y asociaciones: enfermedad renal, leucemia, cáncer de pulmón, Alzheimer, hepatitis C

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– Genome-wide association studies identify the role of caspase-9 in kidney disease
– Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
– Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment
– Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics
– Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population

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ADN circulante para diagnóstico de cáncer de pulmón

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Los fragmentos de ADN tumoral circulante en sangre periférica, junto a otros elementos clínicos, permitió identificar el 94 % de pacientes con cáncer de pulmón, y aportó un indicador pronóstico de supervivencia, de acuerdo con Mathios D, Johansen JS, Cristiano S, Medina JE, Phallen J, Larsen KR, et al. Detection and characterization of lung cancer using cell-free DNA fragmentomes. Nature Communications, 2021;12:5060.

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